Post Doctoral Fellow - Pathology
Post Doctoral Fellow - Pathology
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$ 58656 - 80000
1 Vacancy
Job Description
Department:
SOM KC Pathology and Lab MedicinePathology & Laboratory MedicinePosition Title:
Post Doctoral Fellow PathologyJob Family Group:
Professional StaffJob Description Summary:
Postdoctoral scholars at the University of Kansas Medical Center are individuals who have received their terminal degree and who have opted to pursue further training in a postdoctoral appointment. Postdoctoral scholarship is a timelimited appointment the primary purpose of which is to provide research and/or scholarly training for an academic or research career. A postdoctoral scholar at KUMC is expected to: Participate in a fulltime regimen of advanced training and research train under the supervision of a faculty research mentor who will provide the opportunity for collaborative and independent research as well promote publication of findings and preparation of research grants as determined by a mutual agreement between the postdoctoral scholar and the mentor participate in relevant academic activities related to the preparation for a career in research or academia participate in the Universitys Individual Development Plan policy for postdoctoral scholars have a PhD or equivalent terminal degree (such as MD DVM PsyD PharmD etc. and candidates should have strong English skills and demonstrate an ability to write and communicate with a scientific audience. Candidates must be able to independently plan multitask and complete projects. Ideally the fellow will be expected to design and execute experiments analyze data write and prepare independent grant applications and manuscripts for scientific publications and supervise graduate students.Job Description:
Job Duties Outlined:
Research Overview:
- Develop and validate an sEVbased detection system for ovarian cancer early detection and disease monitoring. Develop a novel sensitive immunoassay for validating rare EV biomarkers in blood/clinical samples including immunoPCR beadbased EV flow and imagingbased single EV analysis.
- Physical biochemical and molecular characterization of sEVs. Develop and optimize efficient and reproducible EV isolation protocol based on downstream applications.
- Outline LCMS/MS based proteomic experiments for discovery proteomics using clinical samples.
- Establish the proteome of tumorassociated sEVs. Specifically identify unique proteins or distinct pattern of proteins present in sEVs derived from fallopian tube and HGSOC cell lines and tissue explants by mass spectrometry/proteomics; verify the resulting candidate biomarkers by highthroughput capillarybased immunoassays; and isolate sEVs and analyze by immunoassays and immunoprecipitation to prioritize candidate exoproteins for the ovarian cancer fingerprint that can differentiate HGSOC from controls and other ovarian cancer patients.
- Collaborate with crossfunctional teams both inside and outside the institution related to proteomics statistics bioinformatics bioengineering and chemistry disciplines.
- Establish transcriptome of tumorassociated sEVs. Define EVassociated miRNA signatures that have the greatest stability and reproducibility as analytes to differentiate earlystage ovarian cancer cases from benign disease and healthy controls.
- Work with clinical samples including serum plasma patientderived tissue ascites for EVbased biomarker discovery
- Mammalian cell culture for isolation of sEVs. Cell engineering to express new functionality or silence genes of interest for EVbased biomarker discovery and validation.
Expectations:
- Perform research techniques in a laboratory setting conduct independent research.
- Work closely with the PI and laboratory members on research projects and in the preparation of data and writing for grants. Seek and apply for internal and external grants.
- Independently write manuscripts for academic publication. Present data to various groups and scientific conferences.
- Work as a team with other lab members. Help to lead multiinstitutional collaborative projects with multiple PIs. Communicate effectively to execute various projects in a timely manner.
- Assist with overall maintenance of the lab.
- Mentor and direct the work of junior scientists graduate students and summer students.
- Other duties as assigned by the lab PI.
Compliance: Maintain compliance on all orientation and training sessions designated by the University and the Department understand and follow IACUC and biosafety protocols and attend seminars of interest lab meetings and other meetings associated with ongoing projects.
This job description is not designed to cover or contain a comprehensive listing of activities duties or responsibilities that are required of the employee for this job. It is only a summary of the typical functions of the job not an exhaustive list of all possible job responsibilities tasks duties and assignments. Furthermore job duties responsibilities and activities may change at any time with or without notice.
Required Qualifications:
Education: PhD biochemistry molecular biology or related biological sciences degree
Work Experience: Demonstrated ability to work in cancer research (focus will be on epithelial ovarian cancer and potentially gastrointestinal stromal tumor) extracellular vesicles (focused on small EVs) and technical expertise in proteomics and transcriptomics will be a plus.
Preferred Qualifications:
Education: PhD in biological sciences or MD with extensive research experience.
Work Experience:
- Expertise in tumor biology and/or molecular cancer genetics and with prior experience in molecular biology techniques including EV purification and characterization fluorescent/confocal microscopy (ICC and IHC) EVs labeling and tracking flow cytometry protein analysis (Western blot ELISA and IP) cell culture work immunoassays NGS pRTPCR DLS NTA Affy microarrays NanoString ncounter profiling etc.
- Experience with the initiation and/or participation in successful collaborative research projects.
- Demonstrated experience writing peerreviewed publications.
Skills:
- Communication skills for manuscript and grant writing oral presentation skills in both technical and lay forums.
- Collaborative and management skills.
Required Documents:
- Resume/CV
- Cover Letter
Comprehensive Benefits Package:
Coverage begins on day one for health dental and vision insurance and includes health expense accounts with generous employer contributions if the employee participates in a qualifying health plan. Employerpaid life insurance longterm disability insurance and various additional voluntary insurance plans are available. Paid time off including vacation and sick begins accruing upon hire plus ten paid holidays. One paid discretionary day is available after six months of employment and paid time off for bereavement jury duty military service and parental leave is available after 12 months of employment. A retirement program with a generous employer contribution and additional voluntary retirement programs 457 or 403b) are available. Type: Regular Compensation Statement: The pay range listed for this position is determined by our compensation program using market data and salary benchmarking. A combination of factors is considered in making compensation decisions including but not limited to education experience and training qualifications relative to the requirements of the position and funding. At the University of Kansas Medical Center a reasonable estimate for the starting pay range will be the minimum to midpoint of the posted range taking into account the combination of factors listed above. Minimum Midpoint MaximumTime Type:
Full timeRate Type:
SalaryPay Range:
$58656.00 $80000.00
Employment Type
Full-Time
Key Skills
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