Scientist TCR Discovery
Scientist TCR Discovery
Posted on :
05-04-2025
Employer Active
1 Vacancy
Job Alert
You will be updated with latest job alerts via emailValid email field required
Send jobs
Share
Send me jobs like this
Job Alert
You will be updated with latest job alerts via emailValid email field required
Send jobs
Monthly Salary
Not Disclosed
Salary Not Disclosed
Vacancy
1 Vacancy
Posted on :
05-04-2025
Job Description
The Research & Development (R&D) organization at BlueSphere Bio aims to accelerate the translation of innovative research discoveries into new cancer therapeutic medicines through the collaboration with CMC clinical and business development functions.
Job Description
We are seeking an Scientist I/Associate Scientist to join BlueSphere Bios Tcell Receptor (TCR) Discovery team. The incumbent will use stateoftheart instrumentation and techniques for the identification of TCRs that recognize minor histocompatibility antigens as well as tumorassociated antigens and neoantigens. Additionally she/he will work with a group of individuals developing a highthroughput platform that is able to isolate and identify rare antigenspecific Tcells from healthy and patient donor samples. Candidates interested in expanding their knowledge and gaining experience in cellbased (TCRT) cancer therapies and drug discovery are highlyencouraged to apply.
Duties and Responsibilities may include
- Process characterize and coordinate the genotyping of primary human blood/PBMC samples
- Apply highthroughput cell culture techniques for establishing cocultures of primary Tcells with antigenpresenting cells
- Transduce and/or electroporate antigenpresenting cells with lentivirus or plasmid constructs
- Analyze Tcells and Tcell receptor function via flow cytometry
- Perform molecular biology techniques as the project requires for the cloning and detailed characterization of TCRs
- Develop assays for highthroughput screening of Tcells and TCRantigen reactivity
- Maintain accurate sample and laboratory records
- Organize and conduct assigned studies with a highdegree of independence and attention to detail
- Present scientific results to peers and management during regularly scheduled lab meetings
Required & Preferred Qualifications
- PhD in Cancer Biology Immunology Cell Biology Molecular Biology or related fields is required
- Handson research experience in an academic or industry setting is required
- A record of advancing projects as evidenced by publications or patents is required
- Indepth knowledge of cellular biology is required
- Demonstrated work in cell culture techniques including designing setting up and performing cellbased assays is required
- Experience in Tcell enrichment expansion and characterization is preferred
- Previous exposure to flow cytometry is required
- Experience in cell line development is required
- Experience in cellular transfection lentivirus production and transduction is required
- Experience in assay/platform development is preferred
- Proficiency with analytical software packages e.g. SnapGene PRISM FlowJo and Excel is preferred
- The ability to adhere to timelines and milestones in an organized manner is required
- Excellent communication and presentation skills are preferred
- Demonstrated ability to independently identify issues and troubleshoot
- You will be expected to occasionally 1 to 20 of the time):
- Climb stairs ramps ladders. Etc.
- Stoop/crouch by bending your legs or bending down/forward at the waist
- Reach by extending the hands/arms
- Lift objects from one level to another 30 lbs. or less)
- Carry objects 30 lbs. or less)
- Travel (up to 20
- You will be expected to frequently 21 to 50 of the time):
- Walk around the facility on foot
- Stand on your feet
- You will be expected to constantly (at least 51 of the time):
- Sit in a normal seated position
Employment Type
Full-Time
Key Skills
Report This Job
Disclaimer: Drjobpro.com is only a platform that connects job seekers and employers. Applicants are advised to conduct their own independent research into the credentials of the prospective employer.We always make certain that our clients do not endorse any request for money payments, thus we advise against sharing any personal or bank-related information with any third party. If you suspect fraud or malpractice, please contact us via contact us page.
