Scientist I Analytical Development-NGS
Scientist I Analytical Development-NGS
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Job Description
Why Sarepta Why Now
The promise of genetic medicine has arrived and Sarepta is at the forefront. We hold leadership positions in Duchenne muscular dystrophy (DMD) and limbgirdle muscular dystrophies (LGMDs) and we currently have more than 40 programs in various stages of development in gene therapy RNA and gene editing. In 2023 we launched our fourth therapy and the first ever gene therapy to treat Duchenne.
Were looking for people who see unlimited potential in themselves and who are motivated by an unwavering commitment to patients.
What Sarepta Offers
At Sarepta we care deeply about all the people in our community and believe in the importance of supporting them in all aspects of their lives. We aspire to maintain a culture that acknowledges people bring their whole selves to work and we will strive to help everyone in our community integrate their work and personal lives while maintaining productivity. We are committed to offering a range of benefits and worklife resources designed to support people in the following areas:
Physical and Emotional Wellness
Financial Wellness
Support for Caregivers
For a full list of our comprehensive benefits see our website: Importance of the Role
As a member of the Early Research Process Development Analytical Development group this position will be responsible for the design and optimization of longread DNA sequencing methods for evaluation of AdenoAssociated Virus (AAV). The individual must have handson experience in using next generation sequencing (NGS) platforms data analysis and method troubleshooting. The individual will collaborate with Early Research Process Development Gene Therapy Research and additional internal and external stakeholders to ensure the development and transfer of robust analytical methods.The Opportunity to Make a Difference
- The successful candidate with be responsible for the following:
- Design optimization and of NGS projects on the PacBio Vega sequencing platform including:
- DNA extraction isolation and purification from AAV
- DNA library preparation for long read sequencing
- PacBio sequencer operation
- Data quality monitoring
- Data analysis and validation
- Indepth understanding of principles and methods for sequencing analysis
- Identifying and implementing operational improvements and novel technologies to solve analytical problems
- Work seamlessly with crossfunctional stakeholders
- Participate in project related teams and other internal/external collaborations
- Ensure that scientific and technical challenges are resolved in a timely manner
- Maintain all appropriate laboratory records author technical documents protocols and reports
- Perform routine data analysis and visualization for use in presentations publications and internal reports
- Contribute to a safe efficient and effective environment with personal accountability
- Perform other related duties as required
- Design optimization and of NGS projects on the PacBio Vega sequencing platform including:
More about You
- PhD Degree in Bioinformatics Biostatistics Biotechnology Biochemistry or related field
- 13 years of related experience in method development and analysis in gene therapy and/or viral vector biology preferred
- Extensive handson experience with sequencing analysis tools and scripting/programming for bioinformatics (command line bioinformatics)
- Adaptable to the evolving field of bioinformatics
- Handson experience of NGS library preparation
- Experience working with liquid handling workstations
- Experience with Capillary Electrophoresis is desirable
- DNA/RNA quality control experience e.g. TapeStation or equivalent is desirable
- Ability to develop and troubleshoot methods with minimal supervision
- Excellent written and verbal communication skills
- Proven record of successfully planning experiments and executing projects in collaboration with internal or external stakeholders
- Proven ability to work independently and effectively handle multiple priorities is a must
- Ability to maintain confidentiality of proprietary information expected
What Now
Were always looking for solutionoriented critical thinkers.
So if youre comfortable with ambiguity and candor relish challenging yourself and place kindness and integrity at the forefront of how you approach your peers and work then we encourage you to apply.
Employment Type
Full-Time
