ScientistSr Scientist Genome Engineering
ScientistSr Scientist Genome Engineering
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1 Vacancy
Job Description
tl;dr
General Proximity is a seedstage startup developing the next generation of induced proximity medicines (IPMs). Our OmniTAC drug discovery engine furnishes molecules that coopt existing cellular machinery to overcome therapeutic challenges which have remained unapproachable to other modalities for decades.
We are seeking a firstrate Genome Engineer to help us pioneer this uncharted frontier of drug discovery.
Our Story
A longstanding challenge in drug discovery is the development of molecules capable of modulating difficult or undruggable targets. Diseasecausing proteins can be dysfunctional in many different ways but our armamentarium for fixing them is quite limited. The most common mechanism of action for FDAapproved is inhibition1 but there are many other possible perturbation types whose potential remains unrealized.
General Proximity is a seedstage drug discovery company developing a novel platform technology to solve this problem. We make bifunctional that induce the modification of drug targets by existing cellular machinery (rather than through direct modulation by the drug the classical approach).
Historically the development of technologies that allow one to push new buttons in biology has been an incredibly fertile field for the discovery of new medicines2 3 4 and our technology holds the same promise.
The Position
We are seeking an experienced Genome Engineer to be a founding member of our Platform/Bioengineering Team. In this position you will work in close conjunction with our Biology Team in the development of our core drug discovery technology and the generation of a completely novel class of therapeutics.
About You
High Agency. Initiative independence and selfaccountability are some of our most valued traits.
Enthusiastic. We love people who are excited about what they are doing and are generally attempting to build a highenergy team.
Intensity and Grit. Earlystage startups are hard. Drug discovery is doubly so. We are looking for candidates who have a demonstrated ability to stick with complex problems for the long haul with a team that has your back along the way.
Prosocial. We are here to create lifesaving medicines for the patients who need it most. You should be too.
Required Qualifications:
- PhD in Molecular Biology Genetics Biochemistry or a closely related field
- Minimum of 2 years postdoctoral experience in academia or the biotechnology industry
- Demonstrated expertise in genome editing and engineering techniques particularly CRISPR systems and vector design for gene editing applications
- Experience with lentiviral library construction highthroughput pooled screening FACS sorting and NGS data analysis
- Experience with automation tools for highthroughput screening
- Proficiency in molecular cloning techniques such as Gibson assembly Gateway cloning and PCR to design and construct vectors for gene editing applications
- Strong analytical skills and experience with data analysis and visualization software (e.g. R Python MATLAB)
- Knowledge of cell line engineering and generation of stable cell lines
- Excellent written and oral communication skills for effective team collaboration and scientific reporting
Nice to Have:
- Prior experience on teams that have successfully advanced research to the clinic
- Familiarity or experience with PROTAC/nextgen IPM technologies
- Experience with PPI techniques (e.g. BRET APEX/BioID AlphaScreen etc.
- Advanced gene editing techniques such as Prime or Base Editing
Key Responsibilities in this Role:
- Design and perform nested PCR to amplify ORFs from genomic DNA and construct lentiviral libraries for ORFeome screening
- Implement highthroughput genomics assays including pooled library construction and screening with subsequent FACS sorting
- Analyze sequencing data from pooled screens using advanced bioinformatics tools and statistical packages such as STAR aligner Bowtie and edgeR
- Conduct cell line generation including the creation and maintenance of stable cell lines and inducible systems for gene expression
- Optimize protocols for viral production transduction and titering of lentiviral particles
- Execute arrayed and fluorescencebased screens with proficiency in flow cytometry analysis
- Collaborate with interdisciplinary teams to refine screening assays and troubleshoot experimental procedures
Benefits
- Strong equity incentives. We are looking for candidates who will bring a strong sense of ownership to drive their project areas forward and we believe that you deserve to be compensated accordingly.
- Top tier medical dental and vision coverage One Medical membership.
- 401(k) retirement plans.
- Education and health/fitness incentive programs.
- Meditation retreatsdo a tenday Vipassana retreat without counting towards vacation days.
- Reading budget! We will buy you books.
- Located in the MBC BioLabs at 135 Mississippi Street an entrepreneurial hub full of the best scientists and operators the Bay Area has to offer. Our lab is a very short walk from the 22nd St Caltrain Station and a number of wonderful restaurants and cafs.
About Us
Work Hard/Play Hard. We believe time is our most valuable commodity so we strive to create a culture that reflects this. We wont drag you through unnecessary meetings or email you at 7 PM on a Saturday. When were at work were there to get things done and when were off were really off.
Strong Communication. We like wellwritten documents over PowerPoints OKRs over vague mission statements and weekly oneonones over yearly reviews.
Writing First. We have a writingfirst culture. We believe that clarity of writing reflects clarity of thinking and that the benefits of wellwritten documentation in a scientific environment are innumerable: democratization of ideation and decisionmaking increased reproducibility quicker scaling and onboarding and better companywide alignment to name a few.
Growth. As an earlystage startup we value scientists with an independent cando attitude. The more hats you can wear the better. Our job as employers is to put you in positive feedback loops so you can grow in the direction of your choosing.
Title and compensation commensurate with experience. Applications from candidates of diverse backgrounds women and members of underrepresented minority groups are particularly welcomed. We look forward to hearing from you. :
More info atjobs.generalproximity.bio
Required Experience:
Senior IC
Employment Type
Full Time
