Scientist Cell Pharmacology
Scientist Cell Pharmacology
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Job Description
Scientist Cell Pharmacology
Xilio Therapeutics is a clinicalstage biotechnology company discovering and developing tumoractivated immunooncology (IO) therapies with the goal of significantly improving outcomes for people living with cancer without the systemic side effects of current IO treatments. The company is using its proprietary platform to advance a pipeline of novel tumoractivated clinical and preclinical IO molecules that are designed to optimize the therapeutic index by localizing antitumor activity within the tumor microenvironment. Learn more by visitingwww.xiliotx.comand follow us on LinkedIn Xilio Therapeutics Inc..
SUMMARY:
The Scientist Cell Pharmacology is a member of the Cellular Pharmacology group and will support Xilios growing immunooncology pipeline. Reporting to the Associate Director Cell Pharmacology this key role offers the opportunity to directly contribute to Xilios cutting edge immunooncology programs by developing assays and generating decisionmaking data. This role provides an exciting opportunity to directly influence ongoing programs and contribute to the discovery of new to treat cancer patients.
Job Responsibilities:
- Work as an integrated member of the research team to generate data to support ongoing drug discovery efforts.
- Serve as expert on cellbased assays to support discovery and development programs.
- Research relevant literature to devise cellular functional experiments. Implement and execute cellbased assays such as phenotypic assays and reporter gene assays (RGA) which assess drug candidate activity and mechanism of action.
- Develop assays to characterize and analyze protease activity in different biological samples including measurement of substrate cleavage kinetics to support understanding of protease activity in human disease.
- Prepare dissociated cell suspensions from fresh human tumor tissues to understand molecule function in the context of cancer.
- Develop and run ligand binding assays.
- Perform gel electrophoresis and western blot assays to assess recombinant proteins.
- Capture detailed experimental information and data analyses in electronic lab notebook (ELN) entries.
- Represent Cell Pharmacology at project team meetings.
- Provide assay development expertise to support manufacturing sciences nonclinical DMPK and Tox studies.
Skills Qualifications and Requirements:
- PhD in Biology Cell Biology Biochemistry or similar subject with 01 years biotech/ pharma experience or BS/MS in Biology Cell Biology Biochemistry or similar subject with 4 years (BS) or 2 years (MS) biopharma experience.
- Mammalian cell culture experience is essential.
- Technical experience in the development qualification and of cellular phenotypic assays is highly preferred.
- Previous experience with FACS ELISA and MSDbased readouts.
- Prior experience working with proteases is a plus.
- Experience with Western blots CESDS and recombinant proteins.
- Generation of genetically engineered cell lines and/or experience with CRISPR is a plus.
- Goal oriented organized capable of working on multiple projects and able to execute to timelines that meet company goals.
- Willing to learn new techniques and skills.
- Work well in a crossfunctional team environment both independently as well as being willing to help others.
- Excellent verbal and written communication skills.
Diversity Equity and Inclusion
At Xilio Therapeutics we foster a culture of equity diversity and inclusion. We consider all qualified applicants without regard to race color sex gender identity or expression sexual orientation age religion national origin ancestry ethnicity disability veteran status genetic information or any other characteristic protected under applicable law. We will make reasonable accommodations absent undue hardship for qualified individuals with known disabilities. If you are an individual with a disability who requires an accommodation with the hiring process or to perform any essential functions of the position for which you are applying please reach out to
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Employment Type
Full Time
