Principal Scientist Neuroscience & High Content Imaging

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Our expertise in Innovative Medicine is informed and inspired by patients whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Join us in developing treatments finding cures and pioneering the path from lab to life while championing patients every step of the way.

Learn more at are seeking an exceptional Principal Scientist to help advance our neuroscience discovery efforts through high-content imaging and disease-relevant cellular models in neurodegeneration. This is an opportunity to contribute to science that can meaningfully shape how we understand disease biology guide critical pipeline decisions and ultimately support the development of future therapies for patients with significant unmet need. The successful candidate will join an industry-leading team with deep expertise in complex models and high-content imaging offering a uniquely strong environment for scientific excellence and collaboration. The successful candidate will bring deep scientific expertise curiosity and collaborative leadership to build innovative assay and imaging approaches generate impactful insights from complex model systems and help push ambitious discovery programs forward in a highly connected research environment.

Key Responsibilities

1) Hands-on assay development in neurodegeneration models

• Develop optimize and execute assays in complex in vitro models including primary models aggregation models and cell lines to address diverse scientific questions while ensuring robustness relevance and scalability.
• Generate high-quality reproducible data in physiologically relevant laboratory models to enable compound profiling and deepen biological understanding.
• Interpret complex datasets and translate findings into clear scientific recommendations for project teams and cross-functional stakeholders.
• Drive mechanistic insight by integrating assay outcomes from diverse cellular systems with broader pharmacology and translational data.
• Apply scientific expertise in neuroscience and neurodegeneration to select the most appropriate model systems and assay approaches based on the research questions program stage and decision-making needs.
• Document experimental work with rigor and communicate results clearly in team discussions reports and project updates.

2) Highcontent imaging and analysis in neurodegeneration models

• Own high-content imaging workflows in cellular pharmacology including experimental design acquisition settings quality control troubleshooting downstream analysis and data interpretation.

• Lead hands-on imaging efforts in complex and physiologically relevant models for neurodegeneration.
• Provide technical expertise across imaging modalities including high-content imaging live-cell imaging and confocal/spinning-disk microscopy and apply the most appropriate modality to the scientific question.
• Analyze high-content imaging data in complex models (e.g. neuronal systems co-cultures and 3D models) quantify relevant phenotypes markers and cellular states and generate meaningful readouts that distinguish healthy versus disease or treated versus control conditions.

3) Leadership expectations

• Acts as a senior hands-on scientist within neuroscience programs bringing deep technical expertise strong experimental judgment and a high standard of scientific rigor.
• Leads by example through scientific excellence rigorous execution and generation of high-quality reproducible data.
• Takes ownership of scientific questions and experimental approaches within their area of expertise and contributes clear data-driven recommendations to project teams.
• Works collaboratively across functions and contributes as a trusted scientific partner to program progress and team success.
• Provides mentorship and scientific guidance to junior scientists helping build technical capability and scientific confidence across the team.

Required Qualifications

• Ph.D. in Biomedical Sciences Neurosciences or equivalent industry experience.
• At least 5 years of industry experience in drug discovery or translational research.Deep hands-on experience in neurodegeneration-relevant cellular models including neuronal aggregation models and other disease-relevant in vitro systems used for mechanistic studies phenotypic profiling and translational decision-making.
• Proven hands-on expertise in high-content imaging including assay development image acquisition data analysis and interpretation in complex cellular systems within a cell biology or drug discovery setting.
• Ability to define and implement quality metrics for assay robustness and reliable imagebased readouts.
• Proven ability to independently plan work troubleshoot keep meticulous records and communicate results to crossfunctional partners.

Preferred

• Experience programming in R or Python for high-content imaging data analysis.

Key Competencies

• Strong bench-based scientific judgment in neuroscience and neurodegeneration research.
• Scientific rigor attention to detail and meticulous record-keeping.
• Collaborative mindset and ability to work effectively with cross-functional stakeholders across multiple projects and priorities.
• Practical problem-solving skills including the ability to translate complex datasets from translational models into clear decision-relevant scientific recommendations.

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The anticipated base pay range for this position is:

Benefits:

In addition to base pay we offer the following benefits*: an annual bonus with set target (% of pay) depending on pay grade / location where the actual amount is based on the employees and companies performance of the previous calendar year or sales commissions. Moreover we offer vacation days parental leave for a minimum of 12 weeks bereavement leave caregiver leave volunteer leave well-being reimbursement programs for financial physical and mental health. We also offer service anniversary and recognition awards and subject to the terms of their respective plans employees - and in some locations eligible dependents - can participate in several insurance plans. For more information visit Employee benefits Supporting well-being & career growth Johnson & Johnson Careers.

*This is for informative purposes only. Amounts and actual benefits may vary by location and are subject to change.