Senior Director, Translational Biomarkers

Summary of Position:

We are seeking a highly innovative and motivated scientist to join the Research Department as a Senior Director Translational Biomarkers. This individual will evolve and lead the Translational Biomarkers function that is responsible for defining and implementing biomarker strategies to inform translational oncology objectives for our ADC and immuno-oncology pipeline. Key areas of focus will include defining optimal target populations/patient segments predictive efficacy and safety biomarkers PK/PD relationships mechanisms of drug resistance and supportive evidence for combination strategies. This role will require cross-functional collaboration with pre-clinical and clinical functions and data management as well as with all Translational Medicine functions including translational bioinformatics pathology flow cytometry and toxicology.

Key Responsibilities

• Develop and lead a Translational Biomarkers function within the Translational Medicine organization whose principal remit is to define and implement cutting-edge translational approaches that directly inform both clinical and preclinical development
• Work cross-functionally within Translational Medicine as well as with preclinical and clinical teams to define data-driven rational translational strategies with a clear link to development impact
• Evolve knowledge of and capabilities relating to advanced translational technologies such as spatial -omics and multimodal data analysis designed to elucidate novel insights that inform translational objectives
• Contribute to strategies planning and implementation for CDx development where indicated
• Contribute to development of streamlined operational workflows to ensure efficient translational data handling including but not limited to data import QC processes method development and standardization and criteria for internal/external presentation
• Participate in development of SOPs for translational data analysis that incorporate the use of both internal and external data sources
• Participate in business development activities including establishing and maintaining good collaborative alliance/academic relations
• Participate in and serve in a leadership role for company-wide scientific initiatives
• Promote external visibility through presentations at scientific meetings and through scientific publications

Education and Experience

• MD or PhD in molecular biology or related field
• Minimum of 12 years of related experience in industry/academia with focus on oncology drug development
• A minimum of four (4) years of experience supervising scientific employees

Knowledge Skills and Abilities

• Deep knowledge base in tumor biology and applications to oncology drug development with demonstrable track record in successfully developing applying and implementing translational biomarker strategies with development impact
• Substantial experience designing and implementing data analysis plans in collaboration with data scientists and bioinformaticians
• Broad and thorough understanding of drug development and clinical trial methodology
• Ability to develop innovative analytic approaches to complex problems including the ability to integrate knowledge of biological underpinnings of tumor biology drug mechanism of action and complex multimodal datasets to elucidate critical findings

• Passionate about and experienced in working in a cross-functional and collaborative environment and experienced in influencing across the matrix
• Self-motivated detailed oriented and able to distill complex issues and clearly articulate innovative solutions in a team environment
• Excellent scientific communication skills verbally and in writing in informal 1-1 settings team meetings and formal seminars; Effective communication is essential and includes presentations at cross-functional teams internal review committees external conferences collaborators and partners in addition to writing reports and collaborative scientific publication
• Demonstrated learning agility adaptability collaborative skills strong influencing skills and delivering results through teamwork
• Strong desire to contribute to our mission of translating basic science and expertise into meaningful long-lasting benefit for patients
• Recognized as an expert internally and/or externally in the Translational Medicine arena
• Demonstrates leadership and effective management skills

Supervisory Responsibilities

Associate Director Translational Biomarkers

Additional Information

The annual rate of pay for this position ranges from $229600 $350000. For non-exempt roles and according to applicable regulations there may be the possibility for overtime pay. This role is eligible for the Companys discretionary bonus and discretionary equity incentives. Eligible employees may participate in the Companys benefits programs including medical / dental / vision / prescription coverage employee wellness resources 401(k) plan with employer match access to an Employee Stock Purchase Plan (ESPP) paid time off & paid parental leave benefits and disability benefits.

The annual pay rate range is described in good faith and the Company believes is the range of possible compensation for this role at the time of this posting depending on the candidates experience qualifications geographic location and other factors permitted by law. The Company may ultimately pay more or less than the posted range and this range may be modified in the future. No amount is considered to be wages or compensation until such amount is earned vested and determinable under the terms and conditions of the applicable policies and plans. The amount and availability of any bonus commission benefits or any other form of compensation and benefits that are allocable to a particular employee remains in the Companys sole discretion unless and until paid and may be modified at the Companys sole discretion consistent with the law.

Statement

MacroGenics is proud to be an equal opportunity employer. Employment selection and related decisions are made without regard to race color national origin sex gender identity sexual orientation religion age disability protected veteran status or any other characteristic protected by federal state or local law. We are committed to working with and providing reasonable accommodation to individuals with disabilities. If because of a medical condition or disability you need a reasonable accommodation for any part of the employment process please email or call and/or 711 for TTD/TTY service.

Equal Opportunity Employer/Veterans/Disabled

We do notaccept non-solicited resumes or candidate submittals from search/recruiting agencies.

Required Experience:

Exec